Genes that Escape Silencing on the Second X Chromosome May Drive Disease
Por um escritor misterioso
Descrição
When X-linked genes evade silencing on the “inactive” chromosome in XX cells, some protect women from diseases such as cancer, but others seem to promote conditions such as autoimmunity.
Bisection of the X chromosome disrupts the initiation of chromosome silencing during meiosis in Caenorhabditis elegans
Genes that escape from X‐chromosome inactivation: Potential contributors to Klinefelter syndrome - Navarro‐Cobos - 2020 - American Journal of Medical Genetics Part C: Seminars in Medical Genetics - Wiley Online Library
A schematic diagram of contribution of escape genes to the female bias
Escaping but not the inactive X-linked protein complex coding genes may achieve X-chromosome dosage compensation and underlie X chromosome inactivation-related diseases - ScienceDirect
Frontiers X Inactivation and Escape: Epigenetic and Structural Features
IJMS, Free Full-Text
Not-So-Silent Partners Help Xist Silence X Chromosome
IJMS, Free Full-Text
When the balance is broken: X‐linked gene dosage from two X chromosomes and female‐biased autoimmunity - Syrett - 2019 - Journal of Leukocyte Biology - Wiley Online Library
X-Inactivation, Imprinting, and Long Noncoding RNAs in Health and Disease: Cell
Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution
Gene regulation in time and space during X-chromosome inactivation
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